Detalhe da pesquisa
1.
Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures.
Proc Natl Acad Sci U S A
; 119(48): e2214928119, 2022 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36409889
2.
Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study.
Proc Natl Acad Sci U S A
; 119(24): e2200200119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675429
3.
Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.
Proc Natl Acad Sci U S A
; 119(19): e2202439119, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512094
4.
Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
Proc Natl Acad Sci U S A
; 118(29)2021 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253615
5.
Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine.
Proc Natl Acad Sci U S A
; 117(11): 6086-6091, 2020 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123080
6.
Podocytes are lost from glomeruli before completing apoptosis.
Am J Physiol Renal Physiol
; 323(5): F515-F526, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049065
7.
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity.
Proc Natl Acad Sci U S A
; 116(10): 4575-4582, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30760587
8.
Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models.
Proc Natl Acad Sci U S A
; 116(10): 4592-4598, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30782819
9.
Indirect podocyte injury manifested in a partial podocytectomy mouse model.
Am J Physiol Renal Physiol
; 320(5): F922-F933, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33719575
10.
Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury.
Kidney Int
; 99(3): 620-631, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33137336
11.
Engineered Anti-GPC3 Immunotoxin, HN3-ABD-T20, Produces Regression in Mouse Liver Cancer Xenografts Through Prolonged Serum Retention.
Hepatology
; 71(5): 1696-1711, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31520528
12.
Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity.
Proc Natl Acad Sci U S A
; 115(15): E3501-E3508, 2018 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29581296
13.
Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity.
Proc Natl Acad Sci U S A
; 115(4): E733-E742, 2018 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29311317
14.
5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox.
Proc Natl Acad Sci U S A
; 115(8): E1867-E1875, 2018 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432154
15.
Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin.
Cancer
; 126(22): 4936-4947, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32870522
16.
Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia.
Oncologist
; 25(1): e170-e177, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628266
17.
Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up.
Blood
; 131(21): 2331-2334, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29487070
18.
Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia.
Br J Clin Pharmacol
; 86(7): 1367-1376, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32077130
19.
Results from an international phase 2 study of the anti-CD22 immunotoxin moxetumomab pasudotox in relapsed or refractory childhood B-lineage acute lymphoblastic leukemia.
Pediatr Blood Cancer
; 67(5): e28112, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31944549
20.
Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin.
J Immunol
; 200(6): 2038-2045, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29431691